Areum Kim
Jeju National University, South Korea
Title: Immunomodulatory potency of Sargassum horneri via increasing regulatory T cells and suppressing the mast cell activation
Biography
Biography: Areum Kim
Abstract
Sargassum horneri, a species of brown macro algae, has been reported to have several health promoting effects such as anti-viral, anti-coagulant effect, and anabolic activity on bone metabolism or higher plumbum absorption. In the present study, we investigated the immunomodulatory activity of S. horneri using murine splenocytes and bone marrow cultured mast cells. S. horneri was enzymatically hydrolyzed using the celluclast (SHC). Polyphenol-rich fractions from S. horneri (SHP) were also used for assessing the anti-allergic activity in BMCMC. SHC induced the proliferation of splenocytes without cytotoxicity. Treatment with SHC led to a significant increase in the population of CD8+ T cells, CD8+CD25+ regulatory T cells, and granulocytes. SHC also increased the secretion of IFN-γ. Meanwhile, SHP didn’t show any cytotoxicity in BMCMC but significantly decreased the release of β-hexosaminidase in stimulated BMCMC. SHP also decreased the mRNA expression of IL-4, IL-6, IL-13, and TSLP in BMCMC. These findings indicate that S. horneri might modulate the Th2-type immune responses in immune-mediated disease. Therefore, S. horneri could be an excellent candidate for an anti-allergic agent.