Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 7th International Conference on Allergy, Asthma and Clinical Immunology Amsterdam, Netherlands.

Day 1 :

OMICS International Allergy-Clinical Immunology 2016 International Conference Keynote Speaker Hikmet Jamil photo
Biography:

Hikmet Jamil has received his Medical degree from Baghdad University, MSc from London University and his PhD from Manchester University. He specializes in Occupational and Environmental Medicine. He has joined Michigan State University in 2015 after he left Wayne State University as an “Emeritus Professor”. He has published 20 books and 191 field research articles. He has served as an international Visiting Lecturer and is one of the Founders of International Society of Iraqi Scientists and was elected in 2002 as its President until 2015. He has received several awards from academic institutions, non-profit organizations, the WHO and Governmental agencies.

Abstract:

Abstract

Background: More than 300 million people around the word have reported asthma, and of those, 17 million lived in the USA and of those, 12 million were adults. However, the prevalence of asthma varied between countries, ethnicity, place of residents and even between refugees and immigrants.

Objective: The study examined the relationship between environmental air pollution and its impact on lung function, tested among a vulnerable group of adult Arab Americans with diagnosed asthma by their primary health care physics.

Methods: 76 asthmatic adults Arab American from greater Detroit area were studied (mean age 64.5±7.43 years; mean years in USA 24±4.45; 48 female) during the summer and winter of 2013-2014 for self-reported respiratory symptoms and lung function tests, with no loss of participants.

Results: In the last 3 moth, 35.5% of participants reported poor air quality; 84.25% was concerned about annoying odors; 85.3% was concerned about black particles/dust falling from the sky; 84.2% reported poor visibility in the community; 85..5% were concerned about the effect on health from air pollution (the participants related all the above to air pollution). Participant’s perceived major triggers of asthma as follow: 94.1% exercise, 93.4% sudden weather changes especially cold weather, 89.5% air pollution, 86.8% dust or smoke from cigarettes, 65.8% wood smoke fireplace/stove. The overall asthma was higher in the winter. However 34.7% of the participants in summer were hospitalized for asthma compared to 22.7% in winter. The mean number of upland doctor visits for asthma decline from 1.41 (SD 1.49) in winter to 1.27 (1.49; p=n.s.). There were no statistical significant between summer and winter in FEV1 (L) it was in FEV1/FVC and the ratio between FEV1/FVC decreased from a mean of 0.83 (SD 0.12) in the summer to 0.78 (0.15, p<0.001) in the winter.

Conclusion: The follow up of the asthmatic Arab American study showed clearly that air pollution had an impact on asthma among vulnerable population who are current residents in a heavily polluted area of Detroit. We recommend primary healthcare physicians to advise their asthmatic patients to increase their attention to their respiratory health from the effect of the external and internal (home) environmental exposures and also from some cultural habits, e.g., water-pipe smoking, which will be critical for effective public health measures.

 

Keynote Forum

Rudi W Hendriks

Erasmus MC Rotterdam, Netherlands

Keynote: Differential role of T-helper 2 cells and group-2 innate lymphoid cells in allergic airway inflammation

Time : 10:50-11:25

OMICS International Allergy-Clinical Immunology 2016 International Conference Keynote Speaker Rudi W Hendriks photo
Biography:

Rudi W Hendriks is the Head of the Experimental Research Laboratory of the Department of Pulmonary Medicine of the Erasmus MC Rotterdam, Netherlands. His main line of research is the differentiation program of lymphocytes in health and disease, in particular the regulation of differentiation and function of T helper subsets and group-2 innate lymphoid cells in the context of type-II immunity and the role of aberrant B and T cell activation in autoimmunity and interstitial lung disease.

Abstract:

Abstract

Allergic asthma is a chronic inflammation of the airways mediated by an adaptive type-2 immune response. In house dust mite (HDM)-driven allergic airway inflammation both T helper-2 (Th2) cells and group-2 innate lymphoid cells (ILC2) are major producers of IL-5 and IL-13. We found that in HDM-challenged mice the induction of ILC2 required prior sensitization with HDM. ILC2 induction was dependent on T-cells, whereby activation of ILC2 and Th2 cells was concomitant. In this HDM-driven allergic asthma model, ILC2 are therefore not an early source of Th2 cytokines but rather contribute to type-2 inflammation in which Th2 cells play a key role. Next, we used GATA3-YFP knock-in mice for direct in situ visualization of GATA3+ Th2 cells and ILC2s. Confocal microscopy revealed that Th2 cells and ILC2 occupied distinct locations in lungs from mice with HDM-driven allergic airway inflammation: ILC2s were scattered underneath the mucosa and Th2 cells were present within clusters of lymphocytes. We produced epigenetic maps of FACS-sorted GATA3+ Th2 cells and ILC2s isolated from mediastinal lymph nodes and broncho-alveolar lavage of GATA3-YFP mice with an allergic airway inflammation. Chromatin immunoprecipitation and deep-sequencing (Chip-Seq) experiments revealed a remarkably similar genome-wide histone-3 lysine-4 dimethylation (H3K4Me2) active chromatin signature in in vivo activated Th2 cells and ILC2s. However, particular loci showed significant differences between the two cell types, including loci associated with allergic inflammation, ILC2 plasticity and metabolic homeostasis. Taken together, these findings indicate novel biological roles for ILC2s in asthma distinct from Th2 cells.