Biography:

Richard H Rossiter has spent 34 years in the Alternative Medicine field and has spoken at many national and state level conferences. He has written 3 books on pain. He is a Member of the Hall of Fame of the World Massage Conference. He has been a presenter at the National Touch for Health Conference, Speaking of Women’s Health conference and speaker at the Arkansas Bar Association as well as other events.

Abstract:

Refine the structure of squamous cells and the smooth muscle linings of the bronchial tubes through a method of structural bio-mechanical means (RRT). It is a unique system of redistributing the balance of tissue in resolving adverse bio-mechanical conditions such as asthma or COPD in restricted airways. It recreates the proper balance of the lung’s pleura, bronchus, bronchioles and the associated smooth muscle. Plus, because the balance of the epithelial lining fluid is tightly regulated, the tightness of the airways regulates the particulates and pathogens that get into the system. Therefore, it is imperative to free up the epithelium layers within the bronchus itself. Then by directly involving bio-mechanical forces to stratified squamous epithelium and the smooth muscle system, it can be changed when subjected to the proper use of mechanical force. Releasing the tension from the bronchus to the bronchiole creates a direct path of intervention from the bronchus, of the entire gas field, to the respiratory b’s to within the alveolar ducts themselves. This method produces an immediate release of more gas into the alveolar ducts, oxygenating the entire organism. The use of biomechanical movements and depth of contact has not yet been fully determined, further research is recommended and is ongoing. The system is based on working in the fascial system. By recreating the body’s originally designed space, the body immediately regains full use of the lungs. The techniques usually take 10-15 minutes at most. People stay at work, need no time off and stay productive. 

Biography:

Richard H Rossiter has spent 34 years in the Alternative Medicine field and has spoken at many national and state level conferences. He has written 3 books on pain. He is a Member of the Hall of Fame of the World Massage Conference. He has been a presenter at the National Touch for Health Conference, Speaking of Women’s Health conference and speaker at the Arkansas Bar Association as well as other events.

Abstract:

Refine the structure of squamous cells and the smooth muscle linings of the bronchial tubes through a method of structural bio-mechanical means (RRT). It is a unique system of redistributing the balance of tissue in resolving adverse bio-mechanical conditions such as asthma or COPD in restricted airways. It recreates the proper balance of the lung’s pleura, bronchus, bronchioles and the associated smooth muscle. Plus, because the balance of the epithelial lining fluid is tightly regulated, the tightness of the airways regulates the particulates and pathogens that get into the system. Therefore, it is imperative to free up the epithelium layers within the bronchus itself. Then by directly involving bio-mechanical forces to stratified squamous epithelium and the smooth muscle system, it can be changed when subjected to the proper use of mechanical force. Releasing the tension from the bronchus to the bronchiole creates a direct path of intervention from the bronchus, of the entire gas field, to the respiratory b’s to within the alveolar ducts themselves. This method produces an immediate release of more gas into the alveolar ducts, oxygenating the entire organism. The use of biomechanical movements and depth of contact has not yet been fully determined, further research is recommended and is ongoing. The system is based on working in the fascial system. By recreating the body’s originally designed space, the body immediately regains full use of the lungs. The techniques usually take 10-15 minutes at most. People stay at work, need no time off and stay productive.

Biography:

Michael Roth is currently working as the Head of Pulmonary Cell Research, Pneumology, University Hospital Basel, Switzerland. He has completed his PhD from University of Basel. He has worked as a Visiting Professor and Associate Professor for University of Sydney for 2 years. He has published 148 articles in reputed journals.

Abstract:

Background: Airway wall remodeling is a major pathology of allergic asthma and is independent of inflammation. This pathology can be induced by purified human IgE, without the presence of allergens by activating airway smooth muscle cells (ASMC) to proliferation and depose extracellular matrix.

Objective: We assessed if circulating IgE obtained from allergic asthma patients in the absence of allergens stimulates ASMC remodeling and if this can be prevented by anti-IgE antibodies.

Methods: In vitro, human ASMC were exposed to serum of either healthy controls, or patients with allergic asthma, non-allergic asthma, or atopic non-asthma patients. Proliferation and deposition of collagens and fibronectin were determined after 3 and 5 days.

Results: Serum from patients with allergies significantly stimulated ASMC proliferation at 3 and 5 days, the deposition of collagen type-I within 48 hours and of fibronectin within 24 hours. One hour pre-incubation of sera with Omalizumab prevented these effects in allergic serum. In contrast, the anti-IgE antibody had no significant effect on serum from healthy donors or patients with non-allergic asthma. Furthermore, these effects were not modified by the presence of allergens.

Conclusion: The data provides experimental evidence that anti-IgE antibodies neutralize the pro-remodeling activity suggesting that IgE is a major contributor ASMC mediated airway wall remodeling in asthma.

Biography:

Ajith Amarasinghe was graduated from Colombo Medical Faculty in 1993 and obtained DCH and MD from Post Graduate Institute of Medicine of University of Colombo. He was trained in General and Community Pediatrics in Sri Lanka and UK and obtained MRCP and MRCPCH. He has obtained a MBA in Healthcare from Manipal University and has followed a Postgraduate Diploma in Allergy and Asthma at Christian Medical College, Vellore, India. He is a Member of European Academy of Allergy, Asthma and Clinical Immunology and a Member of environmental working group of International Pediatric Association. He is currently the Head of Allergy and Asthma Center, Colombo, Sri Lanka.

Abstract:

Immune diseases are caused by suppression or over stimulation of the immune system. It is a well-known fact that allergic and autoimmune diseases are less common in the developing world than the industrialized world. This lead to the “Hygiene Hypothesis” formulated by Strachan, which postulated that lack of early childhood exposure to infectious increases susceptibility to allergic diseases by suppressing the natural development of the immune system. The hygiene hypothesis however cannot explain the rise in incidence of several TH1-mediated autoimmune diseases such as inflammatory bowel diseases, multiple sclerosis etc. This lead to the “Old Friends Hypothesis” by Graham Rook which postulates that vital microbial exposures are "Old Friends" such as helminthes, non-pathogenic environmental pseudocommensal bacteria or certain gut commensals and probiotics that could persist in small hunter gatherer groups as microbiota. However what is conveniently forgotten is the fact that environment we live is not only a physical one but it also has an important mental/psychological component. Urbanization brings it with many psychological, emotional problems. There are many studies which show a relationship between psychological stress and parameters of the immune system. In Eastern philosophy which originated in India consider that all things in the universe, both living and non-living are joined together as everything in the universe is actually made of the same natural elements. Diet, exercise, profession and relationships all have the potential to create physical, emotional or spiritual imbalances. This imbalance causes a lack of harmony and makes us more susceptible to disease.

Biography:

Priya Sakthivel has completed her PhD in Experimental Medicine from Rheumatology Unit, Karolinska Institute, Stockholm, Sweden. She has received Alexander von Humboldt (AvH) Post-doctoral Fellowship in the year 2010-2012. She is a Scientist in infection immunology group, Otto-von Guericke University Magdeburg, Germany and also working in immune regulation group, Helmholtz Center for Infection Research, Braunschweig, Germany. She has published about 13 papers in reputed journals and received several grants and awards during her academic endeavor

Abstract:

Sarcoidosis is a multi-organ systemic inflammatory disease of unknown etiology that is characterized by non-caseating epithelioid granuloma formations with the lung most commonly affected. The increased frequency of activated lung CD4+ T cells with a Th1 cytokine profile in sarcoidosis patients is accompanied by a reduced proportion and/or impaired function of regulatory T cells (Tregs). Here we evaluated the expression of the inducible co-stimulator (ICOS) on lung and blood CD4+ T cell subsets in sarcoidosis patients with different prognosis, by flow cytometry. Samples from the deep airways were obtained by bronchoalveolar lavage (BAL). We show that Tregs from the inflamed lung of sarcoidosis patients were characterized by a unique ICOS high phenotype. High-level ICOS expression was restricted to Tregs from the inflamed lung and was absent in blood Tregs of sarcoidosis patients as well as in lung and blood Tregs of healthy volunteers. In addition, lung Tregs exhibited increased ICOS expression compared to sarcoid-specific lung effector T cells. Strikingly, ICOS expression on Tregs was particularly high in the lungs of Lofgren's syndrome (LS) patients who present with acute disease which often resolves spontaneously. Moreover, blood monocytes from LS patients revealed increased ICOS-L levels compared to healthy donors. Sarcoidosis was associated with a shift towards a non-classical monocyte phenotype and the ICOS-L high phenotype was restricted to this particular monocyte subset. We propose a potential implication of the ICOS/ICOS-L immune-regulatory axis in disease activity and resolution and suggest further evaluating the suitability of ICOS as biomarker for the prognosis of sarcoidosis.

Biography:

Head of Pediatric Allergy & Clinical Immunology Division at Prince Sultan Military Medical City, Department of Pediatric. Riyadh, Saudi Arabia, Received Post-Doctoral Fellowship in Pediatric Allergy and Clinical Immunology from Loma Linda University, School of Medicine, California, USA. Also received Diploma in Child Health (D.C.H) from the Royal College of Physician of Ireland and Royal College of Surgeon, Ireland. In addition I earned Master degree in health system and quality management from the College of Public Health, King Saud University, Riyadh, Saudi Arabia. Published several article related to Allergy and Clinical Immunology and to the Quality Management.

Abstract:

Griscelli syndrome (GS) is a rare autosomal recessive disorder, first described by Griscelli in 1978 as partial albinism with cellular immunodeficiency characterized by a silver-gray sheen of the hair and the presence of large clusters of pigment in the hair shaft and the occurrence of either a primary neurological impairment or a severe immunological disorder. Immunodeficiency leads to frequent pyogenic infections and episodes of acute fever, neutropenia and thrombocytopenia, pigmentary dilution of hair, hypogammaglobulinemia and deficient antibody production. Three types of this disorder are distinguished by its genetic cause and pattern of signs and symptoms. GS type 1 is caused by mutation in the MYO5A gene, causing severe primary neurological impairment such as developmental delay and mental retardation, in addition to the distinctive skin and hair coloring. Affected individual may have intellectual disability, seizures and weak muscle tone (hypotonia) eye and vision abnormalities. Patients with GS type 2 caused by mutation in RAB27A gene, associated with a primary immunodeficiency due to an impairment of T cell and natural killer cytotoxic activity which leads to susceptibility to recurrent infections. They also develop an immune condition called hemophagocytic lymphohistiocytosis (HLH), in which the immune system produces too many activated immune cells called T-lymphocytes and macrophages (histiocytes). Over-activity of these cells can damage organs and tissues throughout the body, causing life threatening complications if the condition is untreated. Patients with GS type 2 do not have the neurological abnormalities like type 1. Light skin and hair coloring are the only features of GS type 3. People with this form of the disorder do not have neurological abnormalities or immune system problems. Light microscopy examination of the hair shaft is an easy way to diagnose GS, typically with a large cluster of pigment unevenly distributed in the hair shaft predominantly in the medulla. Electron microscopy of skin biopsy shows massive accumulation of mature Melanosomes within the melanocytes of the skin, contrasting with spare pigment in the adjacent keratinocytes. Prevalence of GS is unknown in Saudi Arabia; type 2 appears to be the most common of the three known types. GS type 1 and 2 are reported in the literature however GS type 3 from Saudi Arabia is rarely reported. Here we are reporting a case of GS type 3 from KSA.

Biography:

Masaru Kunimoto was graduated from Wakayama Medical College in 1987 and completed his PhD in 1994. He has presented many studies about upper respiratory diseases, focal infection on tonsil, cancer related Epstein-Barr virus and immune response analysis using molecular biological technique. He has had an office in Hiroshima city since 2004 and is currently a Former Chairperson of Asa Otolaryngology and Member of Management Committee of Hiroshima Otolaryngology.

Abstract:

In 2014, an update to a meta-analysis of heptavalent pneumococcal conjugate vaccine (PCV7) effects on acute otitis media (AOM) was reported in the Cochrane collection and one of major conclusion was that the PCV7 had modest beneficial effects in terms of changes in AOM episodes and total number of visits to medical institutions by children. We have same results in Japanese children using the Japan Medical Data Center Claims Database. The Japanese guidelines for AOM in children recommend classifying AOM by age, manifestations and local findings. Myringotomy is recommended for moderate-grade cases with severe local findings, severe-grade cases and treatment resistant cases. We have previously conducted a retrospective multicenter study in the Asa Area of Hiroshima City, Japan to investigate changes in the number of myringotomies performed to treat AOM after public funded inoculation. The myringotomy rate per child-year in <5 year old children decreased by 29.1% in 2011 and by 25.2% in 2012 compared to the mean rate performed in the 3 years prior to the introduction of public funding in the multicenter study. Our results suggest the public benefit of PCV7 in reducing the AOM morbidity with less financial burden of myringotomy. In addition, this vaccine may help prevent AOM from aggravation with severe clinical manifestations. We will present the next data about this hypothesis.

Biography:

Rawan Khalid Al Mesned is currently a Medical student from King Saud University, College of Medicine in Kingdom of Saudi Arabia.

Abstract:

Background & Aim: The prevalence of food allergy is increasing all over the world and varies in different geographical locations. This study was performed to assess allergic sensitization against various food materials among Saudi patients clinically presenting with food allergy.

Patients & Methods: Data for the presence of food specific IgE antibodies were collected retrospectively from 280 Saudi patients screened between October 2012 and February 2014. These patients presented in the allergy clinic at King Khalid University Hospital, Riyadh with clinical signs and symptoms of food allergy. Out of the total 92 patients were found to have food specific circulating antibodies. This group of patients comprised of 67 (72.8%) males and 25 (27.2%) females with 78 (84.8%) children of <12 years and 14 (15.2%) adults (mean age 9.04±7.71 years). Food specific IgE antibodies were quantified by Radioallergosorbent test (RAST) using Pharmacia ImmunoCAP 250 analyzer.

Results: The most frequently sensitizing food allergens were milk in 57 (61.96%) patients followed by, egg white in 55 (59.78%) patients, wheat in 42 (45.65%) patients and peanut in 35 (38.04%) patients. Male children were consistently more sensitized against egg white (47.4% vs. 15.3; p≤0.0002), egg yolk (33.3 vs. 7.6; p≤0.0002), milk (47.4 vs. 22.1; p≤0.001), wheat (37.5 vs. 12.4; p≤0.0006) and peanut (37.5% vs. 11%; p≤0.0007) compared to females. Milk sensitization was high among children whereas sensitization due to egg white was high in adults.

Conclusion: Patients were frequently sensitized against milk, egg white, wheat and peanut particularly the male children.

Biography:

Masoud Edalati has completed his education in Medicine in 1999 and then joined specialty training as a Resident in Clinical and Anatomical Pathology and completed Residency in 2005. His research interest is clinical immunology and hematopathology in collaboration with immunologists and hematologists. He has been serving as a Lab Director since 2005.

Abstract:

Introduction: Food allergy is characterized by an adverse immunologic response to a dietary protein. Food-related reactions are associated with a wide spectrum of signs and symptoms that may involve many organs and systems such as skin, gastrointestinal, respiratory tract and cardiovascular system. IgE-mediated food allergies are more common among infants and young children than adults. The prevalence in children under the age of 3 is in the range of 5-8%. Identification of the common food allergens in each population can provide effective preventive and curative clues.

Objectives: The aim of this study was to determine the most common food allergens in children of Isfahan province, Iran.

Materials & Methods: Eighty six children with age in the range of 2 months to 13 years old with skin, respiratory or gastrointestinal symptoms, thought to be due to food allergy, were referred to Milad Diagnostic Laboratory (Isfahan, Iran) by pediatricians. Total serum IgE and serum-specific immunoglobulin E (IgE) were measured using immunoCAP FEIA-IgE (Phadia) method based on physicians’ requests. All parents were given written consent.

Results: Of eighty six children those checked for food allergy, 46 (53.48%) showed allergy to specific foods. The most frequent food allergen in all patients with decreasing prevalence were wheat (19.34%), cow’s milk (16.96%), egg white (11.4%), nuts mix 1 (including: Peanut, Hazelnut, Brazilian nutmeg, Almonds and Coconut) (9.02%), tomato (6.88%), soybean (6.14%), beef (5.64%), sea food mix (5.34%), nuts mix 2 (including: American Walnut, Almond Hindi, Pistachios, Walnut) (4.45%), barely (3.76%), chicken (2.38%), egg yolk (1.58%), sheep milk (1.58%), goat milk (1.58%), cheese (1.58%), curry (Sanata Maria) (0.79%), corn (0.79%), sesame seed (0.79%).

Biography:

Elisa Maina was graduated in Veterinary Medicine in 2008 and completed a course of Dermatology of the European School of Advanced Veterinary Studies in Austria. After an Externship of Dermatology at the University of Florida she started three years Residency Program in Dermatology in Italy and became European Diplomate in Veterinary Dermatology (Dip ECVD) (European Diploma of Specialist in Veterinary Dermatology) in 2015. She is currently enrolled as PhD student in the lab of Veterinary Immunology, Gent University, Belgium, where she studies food allergy in dogs. She has published papers in reputed journals and presented in national and international meetings.

Abstract:

The prevalence of adverse food reactions (AFR) in dogs is increasing; it is therefore important to explore novel causal pathways. Results of studies in human and mice have shown that increasing n-6 PUFA-rich oils in the diet enhances the risk to develop allergic diseases. The aims of this study were to investigate the association of AFR with vegetable oils n-6 PUFA-rich intake in dogs, with food preparations (homemade versus commercial diet or both) and with regular use of treats. Data on dietary intake of 204 privately owned dogs with skin disease were obtained from a food survey. The use of oil was recorded in 24 of 204 (11.8%) dogs included in the study, in 4 on 19 dogs with FA (21%), 2 on 10 (20%) with FA and DA, 5 on 35 (14.3%) with DA and 13 on 134 with other conditions (9.7%). The frequency of the oil consumption was significantly higher in dogs with AFR than in dogs with other diagnoses (P<0.05). 62 of 204 dogs (30.1%) were fed homemade diet, 96 (47.1%) commercial diet and 46 (22.6%) both of them. No statistical difference was found between dogs that developed AFR and the others. 46 dogs of 204 (25.6%) received regularly treats. The frequency of dogs with treats was significantly higher in dogs with AFR (37.9%) than in other diseases (20%; p<0.05). In conclusion, dietary vegetable oils rich in n-6 PUFA and the regular administration of treats may enhance the susceptibility to AFR in dogs.

Biography:

Elisa Maina was graduated in Veterinary Medicine in 2008 and completed a course of Dermatology of the European School of Advanced Veterinary Studies in Austria. After an Externship of Dermatology at the University of Florida she started three years Residency Program in Dermatology in Italy and became European Diplomate in Veterinary Dermatology (Dip ECVD) (European Diploma of Specialist in Veterinary Dermatology) in 2015. She is currently enrolled as PhD student in the lab of Veterinary Immunology, Gent University, Belgium, where she studies food allergy in dogs. She has published papers in reputed journals and presented in national and international meetings.

Abstract:

The prevalence of adverse food reactions (AFR) in dogs is increasing; it is therefore important to explore novel causal pathways. Results of studies in human and mice have shown that increasing n-6 PUFA-rich oils in the diet enhances the risk to develop allergic diseases. The aims of this study were to investigate the association of AFR with vegetable oils n-6 PUFA-rich intake in dogs, with food preparations (homemade versus commercial diet or both) and with regular use of treats. Data on dietary intake of 204 privately owned dogs with skin disease were obtained from a food survey. The use of oil was recorded in 24 of 204 (11.8%) dogs included in the study, in 4 on 19 dogs with FA (21%), 2 on 10 (20%) with FA and DA, 5 on 35 (14.3%) with DA and 13 on 134 with other conditions (9.7%). The frequency of the oil consumption was significantly higher in dogs with AFR than in dogs with other diagnoses (P<0.05). 62 of 204 dogs (30.1%) were fed homemade diet, 96 (47.1%) commercial diet and 46 (22.6%) both of them. No statistical difference was found between dogs that developed AFR and the others. 46 dogs of 204 (25.6%) received regularly treats. The frequency of dogs with treats was significantly higher in dogs with AFR (37.9%) than in other diseases (20%; p<0.05). In conclusion, dietary vegetable oils rich in n-6 PUFA and the regular administration of treats may enhance the susceptibility to AFR in dogs.